In 1989 a group of Serowe residents conceived the idea of a wildlife reserve near Serowe. Serwe Pan, then a cattle post, had been a traditional hunting area teeming with wildlife and the residents wished to re-establish it to its earlier splendour. In 1993 the Ngwato Land Board allocated the land around Serwe Pan to the Khama Rhino Sanctuary Trust.

The site was chosen due to its excellent habitat for rhinoceros, central location and proximity to a Botswana Defence Force (BDF) base, which provides the Sanctuary with 24hr protection at Khama Rhino Sanctuary. Covering approximately 4,300 hectares of Kalahari sandveld, Khama Rhino Sanctuary is centred around Serwe Pan Рa large grass-covered depression with several natural water holes. Serwe Pan provides prime habitat for white rhinoceros and other grazing animals, whilst the denser vegetation in the southern area of the Sanctuary is favoured by browsing animals such as giraffe.

The Khama RhinoSanctuary is a community trust governed by a Board of Trustees who are elected from the local communities of Serowe, Paje and Mabeleapodi. The Vice President of Botswana, Lt .Gen.S.K.I. Khama, Paramount Chief of the Bamangwato, is Patron of the Trust.

The Khama RhinoSanctuary lies 25km north of historic Serowe on the Serowe-Orapa road. Serowe, one of the largest traditional villages in Africa , is the birthplace of Botswana ‘s first President, the late Sir Seretse Khama. Paje and Mabeleapodi are two small picturesque villages within fifteen kilometres of the Khama Rhino Sanctuary.